Four New Sesquiterpene Pyridine Alkaloids from the Roots of Tripterygium wilfordii Hook. f.

ABSTRACT: Investigation of the roots of Tripterygium wilfordii Hook. f. resulted in the isolation of nine sesquiterpene pyridine alkaloids (SPAs), including four previously undescribed compounds 1-4. The structures of all compounds were elucidated by extensive spectroscopic analysis, including NMR and HRESIMS. In particular, compound 1 was found to possess an unprecedented cage-like ether moiety, representing the first report of such a structural feature within this class of alkaloids. All isolated compounds were evaluated for their anti-inflammatory activity using a lipopolysaccharide (LPS)-induced RAW264.7 macrophage model. Compounds 1, 2, and 4 exhibited significant inhibition of nitric oxide (NO) production, with IC₅₀ values of 7.14 ± 1

SUBMITTER: Wang YD 

PROVIDER: S-EPMC12844141 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature