The Effect of Acute Supplementation of Branched Chain Amino Acids on Serum Metabolites During Endurance Exercise in Healthy Young Males: An Integrative Metabolomics and Correlation Analysis Based on a Randomized Crossover Study.

ABSTRACT:

Background

Branched-chain amino acids (BCAAs) are popular as sports supplements due to their ability to enhance performance and recovery. However, the full spectrum of metabolic alterations triggered by acute supplementation with BCAAs in conjunction with exercise remains incompletely understood.

Methods

A randomized crossover trial was conducted in 8 healthy active young males, who received either BCAA or placebo supplementation for three consecutive days prior to a high-intensity cycling test. Plasma samples were collected pre- and post-exercise and analyzed by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, followed by correlation and enrichment analyses.

Results

Acute BCAA supplementation was significantly associated with

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12844224 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature