Immune Dysregulation and Cytokine Profiling in Acute Mycoplasma pneumoniae Pneumonia.

ABSTRACT: Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection characterized by significant inflammatory responses and lung tissue injury. However, the precise immunological mechanisms and temporal dynamics of key cytokines driving pulmonary inflammation in MPP are still unclear. This study aimed to investigate the underlying immunological mechanisms and cytokine dynamics in MPP. We established an acute MPP murine model via intranasal administration of M. pneumoniae. This model recapitulates key features of human MPP, such as robust airway inflammation and cytokine production. Comprehensive analyses were conducted, including histopathology, flow cytometry, and cytokine profiling. Results showed severe inflammatory responses with prominent infiltration of neutrophils

SUBMITTER: Wen Y 

PROVIDER: S-EPMC12844252 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature