Design, Synthesis, and Anti-Hepatic Fibrosis Evaluation of Cordycepin Derivatives.

ABSTRACT: Activation of hepatic stellate cells (HSCs) featuring upregulated expression of α-smooth muscle actin (α-SMA) is recognized as a key driver for hepatic fibrosis, which provides a promising strategy for seeking anti-liver fibrogenic agents via suppressing the activation event. In this study, we designed and synthesized twenty-eight cordycepin derivatives through structural modifications at the C2 position and the C6-NH₂ group of the purine moiety. These compounds were screened for their inhibitory effects on HSC activation by detecting the mRNA expression of α-SMA using quantitative real-time polymerase chain reaction (qPCR) in the LX-2 cell model. Most compounds displayed inhibitory activity comparable to cordycepin, with compound 3a bearing a C2-chloro and a N6-methyl-N6

SUBMITTER: Pan W 

PROVIDER: S-EPMC12844307 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature