Cycloruthenated Imines: A Step into the Nanomolar Region.

ABSTRACT: A new series of promising and easily accessible antiproliferative agents based on cycloruthenated imines of benzene and thiophene carbaldehydes has been developed and fully characterized using UV-Vis spectroscopy, X-ray diffraction, NMR, HRMS, and cyclic voltammetry. The biological activity of these compounds was tested against A2780, cisplatin-resistant A2780, and HEK293 cell lines, and they exhibited nanomolar IC₅₀ values. They also showed a selectivity index of up to 2.5, indicating their potential as promising antiproliferative compounds.

SUBMITTER: Vasil'ev AA 

PROVIDER: S-EPMC12844335 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature