Antimicrobial Functionalized Mesoporous Silica FDU-12 Loaded with Bacitracin.

ABSTRACT: The threats leading to the extinction of humanity accelerate the evolution and development of materials that are capable of providing conditions for preserving health and, implicitly, life. In our work, we developed drug delivery systems based on mesoporous silica which can deliver an antibiotic, bacitracin, in a more controlled manner. The synthesis of the FDU-12 was performed through a sol-gel method and alternatively functionalized with -NH₂ groups or with poly(N-acryloylmorpholine) chains. The loading of bacitracin was performed using the vacuum-assisted method we successfully used to load these mesoporous materials preferentially within the pores as proved by the TGA-DSC results. The release was performed in two types of simulated body fluid (SBF) and this process was evalu

SUBMITTER: Vasile DA 

PROVIDER: S-EPMC12844483 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature