Pangenome graph analysis reveals evolution of resistance breaking in spinach downy mildew.

ABSTRACT: Filamentous plant pathogens secrete effectors to successfully establish host infections. In resistant crop varieties, plant immunity can be triggered by immune receptors that recognize these effectors. Resistant crop varieties are grown in large-scale monocultures imposing strong selection pressure on pathogens, driving rapid evolution of effector repertoires resulting in the frequent breakdowns of resistance within just a few growing seasons. The oomycete Peronospora effusa, responsible for downy mildew on spinach, is an example of a rapidly adapting pathogen, but it is yet unknown how P. effusa can successfully overcome resistance of spinach by genomic adaptations. To close this knowledge gap, we here generated genome assemblies and constructed a pangenome graph for 19 isolates correspon

SUBMITTER: Skiadas P 

PROVIDER: S-EPMC12844528 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature