Therapeutic targeting of oligodendrocytes in an agent-based model of multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a neurodegenerative disease in which misdirected, persistent activity of the immune system degrades the protective myelin sheaths of nerve axons. Historically, treatment of MS has relied on disease-modifying therapies that involve immunosuppression, such as targeting of the blood-brain barrier (BBB) to restrict lymphocyte movement. New therapeutic ideas in the development pipeline are instead designed to promote populations of myelin producing cells, oligodendrocytes, by exploiting their innate resilience to the stressors of MS or restoring their numbers. Given the significant advancements made in immunological disease understanding due to mathematical and computational modelling, we sought to develop a platform to (1) interrogate our understanding of the neuroim

SUBMITTER: Weatherley GR 

PROVIDER: S-EPMC12844537 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature