Exploratory Dietary Approaches for Drug-Resistant Epilepsy Beyond Standard Ketogenic Diet and Fish Oil: A Systematic Review of Preliminary Clinical Evidence.

ABSTRACT: Background: Standard ketogenic diets (KD) and fish oil have established efficacy for drug-resistant epilepsy (DRE), but adherence and variability remain challenging. Objective: The objective of this study is to provide the first systematic evaluation of clinical evidence for emerging dietary interventions for epilepsy-specifically those other than standard KD and fish oil-and to rigorously evaluate their effectiveness and certainty of evidence to address the current gap in dietary management literature. Unlike prior reviews focused on standard KD or carbohydrate-modified versions, this study is the first to synthesize evidence for "non-standard" interventions-including olive oil-based KDs, probiotics, and restrictive gluten/glutamate-free diets-which are typically excluded fr

SUBMITTER: Meng X 

PROVIDER: S-EPMC12844633 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature