Systematic Review and Meta-Analysis of Milk Fat Globule Membrane Supplementation for Mental Well-Being.

ABSTRACT: Background/Objectives: The milk fat globule membrane (MFGM) is a complex structure of polar lipids, gangliosides, and glycoproteins that has demonstrated anti-inflammatory, neuroprotective, and gut-modulatory effects in preclinical and human studies, but its effects on adult psychological outcomes have not been systematically synthesised. Methods: We conducted a systematic literature search across multiple databases using combined relevant keywords and Medical Subject Headings terms, with manual reference checks to ensure comprehensiveness. Of the 35 articles initially identified, 3 randomised controlled trials met the inclusion criteria: adult participants (≥20 years); bovine MFGM supplementation; a placebo or control group; and outcomes measuring stress, anxiety, or depress

SUBMITTER: Mawson C 

PROVIDER: S-EPMC12844699 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature