HPMC-ZnO Nanorods Enhance Hydrophilicity and Contact-Killing Activity on Polypropylene Meshes and Sutures.

ABSTRACT: Background: Biomedical device-associated infections pose major challenges in surgical care, particularly in hernia repair where polypropylene (PP) meshes and sutures are prone to bacterial colonization and biofilm formation. The limitations of antibiotic resistance and toxicity warrants the need of developing innovative antibacterial strategies. Methods: We developed a composite coating of hydroxypropyl methylcellulose (HPMC) and zinc oxide nanorods (ZnO NP) synthesized via thermal decomposition. This coating was applied to PP meshes and sutures to enhance anti-adhesive properties. The study evaluated surface hydrophilicity through water contact angles, estimation of Zn²⁺ ions using inductively coupled plasma-mass spectrometry (ICP-MS), and long-term efficacy over

SUBMITTER: Jana S 

PROVIDER: S-EPMC12844732 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature