TRPV3 channel activity helps cortical neurons stay active during fever.

ABSTRACT: Fever raises body temperature (T_b) from ~37°C to beyond 38.4°C to combat pathogens. While generally well tolerated below 40°C, in rare cases, fever can abnormally elevate neural activity and induce seizures in neurotypical children aged 2-5 years. This study investigates the mechanisms by which neuronal activity is maintained and stabilized during exposure to fever-range temperatures. Recordings of layer (L)4-evoked spiking in L2/3 pyramidal neurons (PNs) of mouse somatosensory cortex revealed four outcomes as temperature increased from 30°C to 36°C and 39°C (fever-range): neurons remained inactive, stayed active, ceased activity, or initiated activity. Roughly equal proportions of neurons ceased or initiated spiking, making the subset of 'STAY' PNs, those that remain active acr

SUBMITTER: Shen Y 

PROVIDER: S-EPMC12844881 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature