Effects of Phytochemicals on Atherosclerosis: Based on the Gut-Liver Axis.

ABSTRACT: Background: Atherosclerosis (AS) is the primary pathological basis for cardiovascular and cerebrovascular events, with its development closely linked to dyslipidemia and chronic inflammation. The gut-liver axis, serving as a core bridge connecting gut microbiota, hepatic metabolism, and systemic inflammation, has gained increasing prominence in AS pathogenesis. Phytochemicals exhibit multifaceted biological activities, yet their mechanisms for preventing and treating AS via the gut-liver axis remain to be systematically summarized. This review aims to summarize the potential mechanisms of phytochemicals interventions in AS from an intestinal-hepatic axis perspective. Methods: A systematic literature search was conducted using PubMed, Web of Science, and Embase, focusing on pr

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12844917 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature