Plasma Phospholipid Biomarkers Related to the Risk of Cognitive Decline in the Elderly: Results from a Cohort Study.

ABSTRACT: Phospholipids provide both structural and functional varieties for neuro cells, and their dysregulation in brain has been related to pathogenesis of cognitive impairment. The reflection of these phospholipid alterations in the blood might serve as biomarkers for the early recognition of cognitive decline risk preceding clinical symptoms and provide potential targets for intervention. In this cohort study, detailed phospholipid molecular profiles including 229 species were quantified. A total of 209 participants aged 60-80 years (including 138 women and 73 men) were followed for one year, during which 32 participants developed significant cognitive decline, defined as a decrease of three or more points in the Montreal Cognitive Assessment score. A biomarker panel of eight phospholipid molec

SUBMITTER: Liu TT 

PROVIDER: S-EPMC12844940 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature