Charge Effects: Influence of Surface Charge on Protein Corona Adsorption Behavior on Liposomal Formulations.

ABSTRACT: Background: Liposomes have been successfully used in clinics as an excellent drug delivery system. However, once they enter the body, they adsorb surrounding proteins and form a protein corona, which affects how liposomes behave in vivo. Therefore, controlling the formation of the protein corona is crucial for achieving effective treatment outcomes. Among the many variables affecting liposome protein corona formation, the composition of the liposomes themselves and the surrounding ionic environment are two particularly critical factors. Methods: In this context, this study selected bovine serum albumin as a model protein to investigate the influence and mechanism of physiologically relevant inorganic ions (magnesium chloride) and varying proportions of cationic lipid componen

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12844955 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature