Phytochemical Optimization and Anti-Inflammatory Mechanism of an Aerial-Part Extract from Echinacea purpurea in DSS-Induced Colitis.

ABSTRACT: Objective: Echinacea purpurea, an herb with diverse pharmacological activities, has its roots widely used for anti-inflammatory and immunomodulatory purposes. Interestingly, its aerial parts, which are also rich in bioactive compounds, remain underutilized. This study aims to optimize the extraction and purification processes to obtain the aerial part extract of Echinacea purpurea (APE-EP) to enhance the content of active constituents and improve its anti-inflammatory and immunomodulatory effects. Methods: We analyzed the chemical composition of APE-EP using HPLC-MS. The intestinal absorption characteristics of APE-EP were evaluated using an ex vivo everted gut sac assay. Furthermore, the anti-inflammatory and immunomodulatory effects of APE-EP were validated us

SUBMITTER: Jia H 

PROVIDER: S-EPMC12845002 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature