Anthelmintic Activity of Protocatechuic Acid Against Ivermectin-Susceptible and Resistant Haemonchus contortus Strains.

ABSTRACT: The frequent and indiscriminate use of all classes of synthetic anthelmintics to deworm small ruminants has decreased their effectiveness in a worldwide problem of anthelmintic resistance. Using active plant metabolites with anthelmintic properties has become a suggested alternative to control parasitic helminths. The present study investigated the ovicidal and larvicidal activity of a fraction (CnF4) containing protocatechuic acid (3,4-dihydroxybenzoic acid) from Chamaecrista nictitans (Fabaceae) and a commercial standard of protocatechuic acid against strains of the parasitic nematode Haemonchus contortus susceptible (HcIVM-S) and resistant (HcIVM-R) to ivermectin, using egg hatch inhibition (EHI) and L3 larval mortality assays. The CnF4 fraction showed an EHI greater than

SUBMITTER: Cortes-Morales JA 

PROVIDER: S-EPMC12845097 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature