Exploring Chemical Composition of the Aerial Parts of Vernoniastrum migeodii and Anti-Inflammatory Activity of the Compounds.

ABSTRACT: Therapeutic strategies that fine-tune epithelial inflammatory responses are highly sought after in respiratory and mucosal disorders, but few molecules selectively target these pathways. Vernoniastrum migeodii (S. Moore) Isawumi (Asteraceae) represents a chemically promising but understudied source of bioactive small molecules. This study aimed to define the metabolite profile of V. migeodii and evaluate the modulation of inflammatory epithelial signaling of the constituents. From the methanolic extract of V. migeodii, five germacranolide sesquiterpenes, vernolide (1), 3'-hydroxylvernolide (2), pectorolide (3), 4'-hydroxypectorolide-14-O-acetate (4) and 4'-hydroxypectorolide (5), together with (6S,9R

SUBMITTER: Yazdani M 

PROVIDER: S-EPMC12845201 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature