Clinical Presentation, Detection, and Immunopathogenesis of Mycoplasma hyosynoviae Field Isolates in Experimentally Inoculated Pigs.

ABSTRACT: Mycoplasma hyosynoviae is a significant pathogen in swine populations, contributing to polyarthritis and lameness in growing pigs. This study characterizes the clinical presentation, pathogen detection, immune response, and lesion development following experimental inoculation with two distinct M. hyosynoviae strains. Pigs were inoculated with either a low- or high-virulence strain and monitored for 18 days. Lameness was observed throughout the study, with affected pigs exhibiting mild to moderate clinical signs. M. hyosynoviae was often detected in the tonsils, while detection in oral fluids was transient. Serum IgG levels increased significantly in the inoculated groups. IL-1β, IL-6, and TNF-α cytokines were elevated only at 7 DPI, whereas IL-8, IL-10, and IFN-γ leve

SUBMITTER: Macedo NR 

PROVIDER: S-EPMC12845361 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature