Efficacy and Safety of CKDB-322, a Combination of Lactiplantibacillus plantarum Q180 and Phaeodactylum tricornutum, for Reducing Body Fat and Abdominal Adiposity in Overweight Adults.

ABSTRACT:

Background

CKDB-322, a combination of Lactiplantibacillus plantarum Q180 and Phaeodactylum tricornutum, has shown anti-obesity potential in preclinical models, although human evidence is still limited. This randomized, double-blind, placebo-controlled, 12-week trial evaluated the efficacy and safety of CKDB-322 in overweight adults.

Methods

Participants were aged 19-65 years; had a body mass index (BMI) of 25-30 kg/m², and a waist circumference of ≥90 cm for men or ≥85 cm for women. They were randomly assigned to receive either CKDB-322, which provided 1.0 × 10⁹ CFU of L. plantarum Q180 and 200 mg of P. tricornutum daily (n = 50), or a placebo (n = 50).

Results

CKDB-322 supplementation resulted in statist

SUBMITTER: Baek HI 

PROVIDER: S-EPMC12845410 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature