Engineering Human 3D Cardiac Tissues for Predictive Functional Drug Screening.

ABSTRACT: Background/Objectives: Cardiotoxicity remains a leading cause of drug withdrawal. Conventional preclinical models, such as two-dimensional (2D) cell cultures and animal studies, often fail to accurately predict human cardiac responses. While 2D cultures lack the complex architecture and dynamic functionality of native myocardium, interspecies differences limit the translational relevance of animal models. The objective of this study was to develop a human-relevant, in vitro platform that enables predictive and functional assessment of drug-induced cardiotoxicity. Methods: Here, we present a high-throughput in vitro platform for cardiotoxicity screening using three-dimensional (3D) cardiac tissues derived from human induced pluripotent stem cells (hiPSCs) within a thermorespon

SUBMITTER: Baruch ES 

PROVIDER: S-EPMC12845478 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature