Linear Polyethyleneimine-Coated Gold Nanoparticles as a Platform for Central Nervous System Targeting.

ABSTRACT: The unique physicochemical properties of gold nanoparticles (GNPs) have made them versatile tools for biomedical applications, such as imaging, therapy, and drug delivery. The surface modification of GNPs with polymers or biomolecules can enhance their colloidal stability and facilitate internalization into cells. However, the efficient and biocompatible delivery to the central nervous system remains a major challenge, as many existing nanocarriers show poor capacity to cross the blood-brain barrier. We developed a method to coat GNPs with linear polyethyleneimine (GNP@PEI) through a chemical reduction bottom-up approach, in which linear PEI hydrochloride acts simultaneously as a reducing and stabilizing agent of colloidal dispersion. This strategy yielded monodisperse spherical GNP@PEI na

SUBMITTER: Byrne AJ 

PROVIDER: S-EPMC12845547 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature