Molecularly Imprinted Polymer Nanoparticles for Lung-Cancer-Cell-Surface Proteomics.

ABSTRACT: The identification and targeting of lung-cancer-cell-surface proteins are important for drug development. Molecularly imprinted polymer nanoparticles (nanoMIPs) offer a synthetic approach for the recognition of proteins on the cell surfaces. This work outlines the use of a novel 'snapshot imprinting' approach to characterize differences in the cell-surface proteomes of lung cancer cell lines (A549, H460, H522) and a non-cancerous cell line (BEAS-2B) to potential protein targets for diagnostic and therapeutic applications. The mass spectrometry-based quantitative proteomics identified 2381 proteins. Fold change and p-value thresholds were used to define statistically and biologically significant differentially expressed proteins (DEPs) across cell lines, yielding 353, 426, and 274 DE

SUBMITTER: Magumba K 

PROVIDER: S-EPMC12845741 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature