Primary Embryonal Rhabdomyosarcoma of the Breast: A Case Report and Literature Review.

ABSTRACT:

Background

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and adolescents, but primary RMS of the breast is exceptionally rare and diagnostically challenging. Imaging findings are nonspecific and can mimic benign adolescent lesions (e.g., fibroadenoma), making timely histopathologic confirmation crucial. Immunohistochemistry for muscle markers - particularly desmin and myogenin - supports definitive diagnosis of embryonal RMS (ERMS).

Case presentation and case discussion

A 14-year-old Arab female presented with a rapidly enlarging left-breast mass and ipsilateral axillary lymphadenopathy. Core biopsy showed small round blue cells with rhabdomyoblastic differentiation; tumor cells were desmin- and myogenin-positive, consistent with ERMS. She receive

SUBMITTER: Al-Bitar A 

PROVIDER: S-EPMC12845833 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature