Long-Term Urban Air Pollution Drives Multi-Stage Neuropsychiatric Disorder Trajectories: A Prospective Cohort Study.

ABSTRACT: Neuropsychiatric disorders constitute an escalating public health challenge worldwide, with growing evidence suggesting that environmental factors like air pollution may contribute substantially. This prospective cohort study investigated the associations between long-term exposure to fine particulate matter (PM_2.5) and nitrogen oxides (NO_x) and the progression of eight neuropsychiatric disorders among 502,356 UK Biobank participants. Using multi-state models, we analyzed three distinct trajectory stages: stage 1 (transition from baseline healthy status to PHQ-4-positive mood disorders), stage 2 (transition from baseline to ICD-10-diagnosed disorders), and stage 3 (progression from PHQ-4-positive status to clinical diagnosis). Nonlinear exposure-response relationships

SUBMITTER: Song Y 

PROVIDER: S-EPMC12845905 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature