Polylactide/Polycaprolactone Nanofiber Scaffold Enhances Primary Cortical Neuron Growth.

ABSTRACT: Spinal cord injury (SCI) remains a major clinical challenge due to the limited regenerative capacity of the central nervous system (CNS). Effective scaffolds for repair must combine mechanical compatibility with host tissue, controlled degradation matching the time course of regeneration, and microarchitectural features that promote neuronal survival. Electrospun nanofibrous scaffolds mimic the structural and mechanical features of the extracellular matrix, providing critical cues for neuronal adhesion and glial modulation in neural regeneration. Here, we fabricated biodegradable poly(lactic acid)/poly(ε-caprolactone) (PLA/PCL) scaffolds using a dichloromethane/tetrahydrofuran (DCM/THF) solvent system to induce surface porosity via solvent-driven phase separation. The DCM/THF solvent syste

SUBMITTER: Shtol VS 

PROVIDER: S-EPMC12845921 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature