Novel Bioinspired Quercetin-Based Polymers for the Sustained Release of Donepezil in Alzheimer's Disease Therapy.

ABSTRACT: This work was inspired by quercetin, a natural bioflavonoid with well-known neuroprotective properties. We synthesized a new functional monomer, 3-acryloxy-3',4',5,7-tetramethylquercetin 1, and used it to prepare, for the first time, a molecularly imprinted polymer (MIP) selective for donepezil, the main drug used in Alzheimer's disease therapy. The polymer was designed to be fluorescent and responsive to pH changes, aiming for controlled drug release. The optimized MIP-4, produced from a 1:1 mixture of the monomer 1 and acrylic acid, was characterized by FTIR-ATR, fluorescence spectroscopy, SEM, and DLS, confirming its chemical composition, morphology, particle size distribution and zeta potential. Adsorption studies showed higher donepezil binding capacity for MIP th

SUBMITTER: Carreiro EP 

PROVIDER: S-EPMC12845978 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature