Tumor cell FAP orchestrates EMT and immune suppression in aggressive localized ccRCC.

ABSTRACT: Background: In contrast to most solid tumors, high immune cell infiltration in clear cell renal cell carcinoma (ccRCC) is associated with poor patient prognosis. The biological mechanisms underlying this paradox remain unclear, particularly regarding tumor cell-microenvironment interactions promoting local invasion and recurrence. This study aimed to identify spatially resolved tumor, immune, and stromal features that define aggressive phenotypes in localized ccRCC. Methods: Multiplex immunofluorescence was performed using a 33-marker panel on 1,728 multi-region tissue cores from 435 surgically treated patients with localized ccRCC. Samples systematically included tumor centers, invasive borders, and adjacent benign tissue. Single-cell analyses quantified immune, stromal, end

SUBMITTER: Pellinen T 

PROVIDER: S-EPMC12846009 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature