Correlation of Polymer-drug Composition with Micelle Properties, Performance, and Cytotoxicity for the Oligoelectrolyte-mediated pH-triggered Release of Hydrophobic Drugs.

ABSTRACT: Polymeric micelles have the potential to improve the efficacy and safety of drug delivery by improving drug solubility, enhancing bioaccumulation and reducing off-target toxicity. Despite excellent safety profiles, a major limitation with polymeric micelles is their inability to rapidly release their payload once they have reached their target, leading to the inadequate delivery of therapeutic doses. To address this limitation, we have developed a novel strategy to impart pH-responsiveness in non-responsive micelles through the co-encapsulation of oligoelectrolytes with drugs. Herein, we investigate the influence of copolymer composition and drug identity in combination with oligoelectrolyte-oligo(2-vinyl pyridine) (OVP)-loading on pH-triggered drug release from micelles and their cytotoxi

SUBMITTER: Hussain MS 

PROVIDER: S-EPMC12846188 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature