Gene-Environment Interactions of Apoptosis-Related Polymorphisms and Urinary Polycyclic Aromatic Hydrocarbon (PAH) Metabolites in Relation to Sperm Cell Apoptosis Among Men Attending Infertility Clinics.

ABSTRACT: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental endocrine disruptors (EDCs) that enter the human body through respiratory, digestive, and dermal exposure. Prolonged exposure has been associated with adverse health outcomes, including carcinogenicity, mutagenicity, and reproductive toxicity. However, whether genetic variation in apoptosis-related pathways modifies the reproductive effects of PAH exposure remains unclear. To investigate gene-environment interactions between urinary PAH metabolites and polymorphisms in apoptosis-related genes in relation to sperm apoptosis, we conducted a cross-sectional study involving 176 male participants from an infertility clinic in Wuhan, China, who completed structured questionnaires and provided biological samples. Ten OH-PAH meta

SUBMITTER: Yi S 

PROVIDER: S-EPMC12846204 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature