Influenza Vaccine Immunogenicity in Hemodialysis Patients.

ABSTRACT: Background: Patients with end-stage renal disease (ESRD) on hemodialysis are at increased risk for severe influenza, and underlying immune dysfunction may limit vaccine-induced protection. Methods: This observational open-label study evaluated immune responses in 93 hemodialysis patients vaccinated with seasonal inactivated influenza vaccine (IIV) during the 2019-2020 (n = 22) and 2023-2024 (n = 71) seasons. Immune responses were comprehensively assessed using hemagglutination inhibition and microneutralization assays to measure antibody levels, together with flow cytometry analysis of key immune cell populations, including plasmablasts, T-follicular helper cells (Tfh), and effector memory T cells (Tem). Results: During the 2019-2020 season, antibody responses in hemod

SUBMITTER: Shurygina AP 

PROVIDER: S-EPMC12846267 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature