Goose Astrovirus Type 2 Causes Intestinal Injury and Disrupts Homeostasis in Goslings.

ABSTRACT: Goose astrovirus 2 (GAstV-2) infection leads to visceral gout and swollen kidneys in goslings, causing a 5-50% mortality rate and significant economic losses for goose flocks. While most studies on the virus's pathological damage have focused on the kidneys, few reports have examined the effects of this fecal-oral pathogen on the digestive system. This study investigated GAstV-2 localization, cellular targets, and its impact on intestinal structure and homeostasis in orally infected goslings. Twenty 1-day-old goslings were randomly assigned to the infected and control groups. Clinical signs, organ lesions, viral distribution, histopathology, and alterations in intestinal cell populations, cytokine expression, and signaling pathways were assessed at 7 days post-infection. GAstV-2 was detect

SUBMITTER: Li X 

PROVIDER: S-EPMC12846611 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature