Dengue Incidence Following Mass Vaccination: An Interrupted Time Series Study in Parana, Brazil.

ABSTRACT: In southern Brazil, dengue transmission in the state of Paraná has shown a significant increase in the number of cases since the first recorded occurrence in 1995, with more frequent outbreaks in the west, northwest, and north of the state. We evaluated the impact of a campaign of dengue vaccination administered to a fraction of the population in 30 municipalities in the state by conducting a 15-year interrupted time-series ecological study using data obtained from an official Brazilian data register. We modeled dengue incidence using Poisson regression adjusted by covariates (demographic, climate, and epidemiological factors), allowing for specific temporal variation for each site. A reduction of 18.7% in dengue incidence rate was estimated for a vaccination coverage of 100%. Although the

SUBMITTER: Costa-Ribeiro MCVD 

PROVIDER: S-EPMC12846613 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature