Evaluation of a Respiratory Syncytial Virus Subunit Vaccine Candidate in IgA-Deficient Mice: Insights into the Role of IgA in Vaccine-Induced Immunity and Protection.

ABSTRACT:

Background/objectives

Respiratory Syncytial Virus (RSV) causes severe disease in infants, the elderly, and immunocompromised individuals, with reinfections linked to poor induction of durable mucosal immunoglobulin A (IgA). We investigated the role of IgA in immunity and protection induced by a RSV subunit vaccine candidate, tFrsc/TriAdj, which consists of a truncated RSV fusion protein (tFrsc) with a tri-component adjuvant (TriAdj).

Methods

Wild-type (IgA⁺/⁺) and IgA-deficient (IgA^-/^-) BALB/c mice were immunized intranasally and subsequently challenged with RSV.

Results

Vaccination with tFrsc/TriAdj induced robust systemic and mucosal IgG, and high lung and serum neutralizing antibodies, in both IgA⁺/⁺

SUBMITTER: Gonzalez Gonzalez L 

PROVIDER: S-EPMC12846617 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature