Genetic Diversity of Vif and Vpr Accessory Proteins in HIV-1 Group M Clades.

ABSTRACT: Vif and Vpr are HIV-1 accessory proteins that create optimal conditions for viral replication. They are considered as potential targets for the development of therapeutic agents. Natural amino acid substitutions in these proteins have previously been associated with disease progression. The aim of this study was to analyze the genetic diversity of Vif and Vpr in HIV-1 group M clades. A total of 5286 sequences were downloaded and analyzed. For 37 clades in group M, the consensus sequences, amino acid natural variation, and clade-specific amino acid residue substitutions (CSSs) were evaluated. Structural analysis and modeling of consensus sequences were performed for subtypes A1, B, C, and D. The average conservation degree in the HIV-1 group M was 86.4% for Vif and 91.3% for Vpr. In both pr

SUBMITTER: Galzitskaya O 

PROVIDER: S-EPMC12846688 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature