T lymphocyte membrane bionic nanomedicine synergizes with radiotherapy for enhancing Mg²⁺-mediated tumor metallo-immunotherapy and preventing recurrence.

ABSTRACT: Background and Aim: Magnesium ion (Mg²⁺)-mediated metallo-immunotherapy effectively promotes the activation of memory T cells, thereby helping to mitigate tumor recurrence following traditional treatments such as radiotherapy (RT). However, factors such as the acidity of the tumor microenvironment, along with the upregulated expression of immune checkpoints induced by RT and Mg²⁺, may compromise its therapeutic efficacy. Material and Methods: In this work, we developed a T cell membrane-coated, hemin-loaded magnesium carbonate nanomedicine (designated as THM). Following intravenous injection, THM catalyzes the hydrogen peroxide generated during RT to induce a burst of reactive oxygen species (ROS), thereby producing a tumor vaccine that promotes dendritic cell maturation and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12846755 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature