Metabolic rewiring and biomass redistribution enable optimized mixotrophic growth in Chlamydomonas.

ABSTRACT: Aquatic photosynthetic systems account for approximately one-half of all global carbon assimilation and could be a significant source of renewable fuels and feedstocks. However, rapid growth and biomass production in algae have not always translated into high product yields, partly because central metabolism is context specific, with metabolic fluxes being influenced by nutrient conditions and other environmental factors. In the green microalga Chlamydomonas reinhardtii (Chlamydomonas), mixotrophic cultures (acetate + light) grow far faster than phototrophic (light only) or heterotrophic (acetate + dark) cultures, even though acetate partially suppresses photosynthesis. Here, an isotopic dilution strategy with unlabeled acetate was combined with ¹³CO₂ transient

SUBMITTER: Koley S 

PROVIDER: S-EPMC12846818 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature