Nab-paclitaxel versus paclitaxel for taxane acute pain syndrome in solid tumors: a systematic review and meta-analysis.

ABSTRACT:

Objective

To quantitatively compare the incidence and symptom-specific risk of taxane-associated acute pain syndrome (TAPS) between nab-paclitaxel (nab-PTX) and paclitaxel (PTX) in adults with solid tumors, with pre-specified stratification by dosing frequency.

Methods

We systematically searched PubMed, Embase and Cochrane Library (to November 30, 2023) for randomised trials comparing nab-PTX versus PTX. After excluding docetaxel and other taxanes, nine head-to-head RCTs (3,699 patients) were pooled using random-effects models. Odds ratios (OR) and risk ratios (RR) were calculated for arthralgia and myalgia, with subgroup analyses by q3w, q4w and weekly schedules. Risk of bias was assessed with RoB 2.0 and publication bias by funnel plots and Egger's test.

Results

Mya

SUBMITTER: Wei L 

PROVIDER: S-EPMC12846926 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature