Venous outflow time profiles: promising imaging biomarkers for futile recanalization in acute ischemic stroke due to large vessel occlusion.

ABSTRACT:

Background

To investigate whether venous outflow (VO) profiles derived from four-dimensional computed tomographic angiography (4D-CTA) correlate with futile recanalization (FR).

Method

This study consecutively enrolled acute ischemic stroke patients with large vessel occlusion (AIS-LVO) who underwent endovascular thrombectomy (EVT) and achieved successful recanalization (modified thrombolysis in cerebral infarction [mTICI] score of 2b-3). An unfavorable functional outcome was defined as a modified Rankin Scale (mRS) score of 3-6 at 90 days after EVT. VO profiles were assessed using 4D-CTA, including the cortical vein opacification score (COVES) and three cortical venous filling (CVF) time points per hemisphere: initial opacification (CVF1), optimal opacification (CVF2), and

SUBMITTER: Wang H 

PROVIDER: S-EPMC12846930 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature