Epithelial extracellular vesicles induce inflammation and neutrophil activation in the Pseudomonas aeruginosa infected cystic fibrosis bronchial epithelium.

ABSTRACT:

Introduction

Cystic fibrosis (CF) is an autosomal recessive disorder, which manifests in many organ systems including the lungs. Chronic inflammation is a hallmark of CF lung disease leading to bronchiectasis and lung function decline. This is worsened by airway colonization and recurrent infections due to opportunistic pathogens such as Pseudomonas aeruginosa [PA], but the crosstalk between host-bronchial epithelium and immune system has been under characterized. Extracellular vesicles have been found to mediate intercellular crosstalk in different lung diseases and EVs have been shown to be increased in the bronchoalveolar fluid of CF patients. We hypothesize that EVs from PA-infected CF bronchial epithelial cells can modulate pro-inflammatory cytokines and neutrophil migr

SUBMITTER: Hirsch MJ 

PROVIDER: S-EPMC12846939 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature