Evaluation of urine glutathione peroxidase 4 in cats with chronic kidney disease.

ABSTRACT:

Introduction

Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation that damages cellular membranes and leads to the end of a cell's life. Glutathione peroxidase 4 (GPX4), the only enzyme capable of the reduction of lipid peroxidation products within cells, is a key regulator of this process.

Aims

The role of GPX4 in feline chronic kidney disease (CKD) has not been previously investigated. This study aims to determine whether urine GPX4 levels are associated with CKD severity in cats and to assess their potential as a progression biomarker.

Methods

Urine GPX4 levels were measured using a commercial feline ELISA kit. The urine-GPX4-to-creatinine ratio (UGCR) was calculated. Fifteen healthy cats, 61 cats with CKD, and s

SUBMITTER: Hsu WL 

PROVIDER: S-EPMC12846965 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature