Inflammation mediates the association between the Prognosis Nutrition Index (PNI) and mortality in acute pancreatitis: evidence from international cohorts.

ABSTRACT:

Background

The prognostic nutritional index (PNI), reflecting nutritional and immune-inflammatory status, has been linked to outcomes across a range of disorders. Its prognostic value in acute pancreatitis (AP) and the potential mediating role of systemic inflammatory response syndrome (SIRS) remain unclear.

Objective

To investigate whether systemic inflammatory response syndrome (SIRS) mediates the linkage between the prognostic nutritional index (PNI) and risk of death from any cause during hospitalization, as well as short- and long-term outcomes, in patients with acute pancreatitis (AP).

Methods

This was an international retrospective cohort study utilizing the U.S. MIMIC-IV dataset (v2.2) and a hospital-based dataset in China, encompassing 2,574 patients diagnose

SUBMITTER: Huang L 

PROVIDER: S-EPMC12846994 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature