Association between cholecystectomy/gallbladder pathology and colorectal polyps: a systematic review and meta-analysis.

ABSTRACT:

Background

Gallbladder-related pathologies may influence colorectal carcinogenesis, yet systematic evaluation of their associations with precursor lesions remains limited. This study addresses critical knowledge gaps by investigating the dual-axis relationship between cholecystectomy/gallbladder pathologies and colorectal polyp risk while elucidating geographical and biological effect modifiers.

Methods

In accordance with the MOOSE/Cochrane guidelines, 27 observational studies were analysed through PROSPERO (CRD420251012876). Comprehensive meta-analysis was performed to assess the effects of cholecystectomy across polyp subtypes and gallbladder pathology (stones/polyps) associations. Heterogeneity was quantified via I² statistics, and pooled odds ratios (ORs) with 95%

SUBMITTER: Li S 

PROVIDER: S-EPMC12847004 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature