Value of intra- and peritumoral ultrasound radiomics for predicting axillary lymph node burden in breast cancer.

ABSTRACT:

Objective

To evaluate ultrasound-based radiomic features, derived from both intratumoral and peritumoral regions, for noninvasive preoperative prediction of axillary lymph node(ALN) burden in breast cancer.

Methods

This retrospective study analyzed data from 300 pathologically confirmed breast cancer patients undergoing preoperative ultrasound. The cohort was randomly divided into a training set (n = 210) and a testing set (n = 90) at a 7∶3 ratio. Primary tumor regions of interest (ROIs) were manually delineated on preoperative ultrasound images using ITK-SNAP. Peritumoral ROIs were generated by radially expanding the intratumoral ROI by 2mm, 3mm, and 4mm. A comprehensive set of radiomic features was extracted from each ROI, with feature selection via LASSO based methods. Si

SUBMITTER: Hao MH 

PROVIDER: S-EPMC12847015 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature