The expression of mercaptopyruvate sulfurtransferase serves as a potential biomarker for prognostic stratification and immunotherapy in certain cancers.

ABSTRACT:

Introduction

3 - Mercaptopyruvate Sulfurtransferase (3 - MST) is an enzyme encoded by the Mercaptopyruvate Sulfurtransferase (MPST) gene. The enzyme is associated with a variety of cancers such as lung adenocarcinoma. However, there is a lack of comprehensive pan-cancer analysis on the potential impact of MPST on cancer diagnosis, prognosis, and immune response.

Methods

Based on data from The Cancer Genome Atlas and the Human Protein Atlas, we conducted a comprehensive bioinformatic analysis to investigate the oncogenic role of MPST. Immune-related characteristics and tumor microenvironment infiltration were assessed using TIMER2.0. Protein-protein interaction networks were constructed via STRING, while DNA methylation differences across cancers were analyzed with UALCAN. Fu

SUBMITTER: Cui B 

PROVIDER: S-EPMC12847049 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature