E3 ubiquitin ligase trim36 targets ddx3x for degradation to reprogram macrophage polarization and ameliorate tubal factor infertility in rats.

ABSTRACT:

Objective

Tubal factor infertility (TFI), a major cause of female infertility, lacks effective therapies and is closely associated with macrophage-mediated inflammation. Although DDX3X regulates macrophage polarization, its specific contribution to TFI pathogenesis remains unclear, and the potential involvement of E3 ubiquitin ligase-mediated regulation of DDX3X protein stability in this condition has not been reported. Therefore, our study planned to explore the regulation of DDX3X by the E3 ubiquitin ligase TRIM36 and how this axis influences macrophage polarization and TFI pathogenesis.

Methods

The GSE262037 dataset and the STRING platform were analyzed through bioinformatics approaches to identify TRIM36, an E3 ubiquitin ligase of DDX3X. A mixed bacterial inoculation met

SUBMITTER: Shao L 

PROVIDER: S-EPMC12847098 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature