Supranutritional Selenomethionine but not Selenite Reduces Malignant Cell Transformation.

ABSTRACT: The trace element selenium is essential to human health and has long been discussed to modulate the carcinogenic process. So far, the functions of selenium and selenoproteins have been mainly studied in already transformed cancer cells. The aim of this study was, therefore, to characterize the role of selenium during the neoplastic transformation process in a concentration- and species-specific manner using the BALB/c cell transformation assay. This assay mimics the initiation and promotion phase of BALB/c cells (murine fibroblasts) treated with a tumor initiator (MCA) and promoter (TPA) leading to malignant cell foci development. In parallel, cells were supplied with selenite or selenomethionine using suboptimal, adequate or supranutritional concentrations (0.01-1 μM). The supranutritiona

SUBMITTER: Meyer CE 

PROVIDER: S-EPMC12847112 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature