Antioxidant Activity and Cytotoxicity of Selenium Incorporated Biologically Inspired N-Heteroaryl Compounds.

ABSTRACT: Selenium is one of the essential trace elements in humans and animals. It is incorporated in the redox-active selenocysteine (Sec), the 21st proteinogenic amino acid, which is found in a limited number of proteins/enzymes. The reactivity of the Sec residue in these proteins allows them to perform diverse functions such as reducing oxidative stress, maintaining redox homeostasis, and thyroid hormone metabolism. An important family of biomolecules is derived from pyridyl-based systems (e.g., 2-pyridinol, 2-nicotinamide). Several of these molecules are also responsible for a wide range of biological activities like redox reactions (e.g., NAD ⇌ NADH; NADP⁺ ⇌ NADPH). Due to their presence in natural systems, these scaffolds are widely used as pharmaceutical motifs in drug design and

SUBMITTER: Jain VK 

PROVIDER: S-EPMC12847152 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature