Apparent diffusion coefficient can assist in differentiating between benign and malignant primary bone tumors in pediatric patients.

ABSTRACT:

Objective

To evaluate differences in apparent diffusion coefficient (ADC) values between benign and malignant primary pediatric bone tumors and to assess their diagnostic accuracy in differentiating these tumors.

Materials and methods

We retrospectively analyzed MRI scans of 96 pediatric patients (54 males, 42 females; mean age 12.97 ± 3.9 years) with primary bone tumors who underwent diffusion-weighted imaging, including 48 benign and 48 malignant tumors. We measured ADCmean, ADCmin, and ADCmax of the solid tumor part, carefully avoiding cystic, necrotic, or sclerosed tumor areas. The Wilcoxon rank-sum test was used to test the distributional difference of benign vs malignant tumors. ROC curve analysis was performed to assess the diagnostic accuracy. The optimal cutoff of A

SUBMITTER: Lokesha YU 

PROVIDER: S-EPMC12847184 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature