The prospective association between high-density lipoprotein (HDL) cholesterol and risk of incident fractures in the general population.

ABSTRACT: Elevated HDL-C levels are generally regarded as prognostically favorable in cardiovascular disease. Our study shows that higher HDL cholesterol levels are prospectively associated with 18% increased risk of new-onset fractures in men but not in women. Higher HDL cholesterol may be a novel risk factor for developing fractures in men.

Purpose

Increased high-density lipoprotein cholesterol (HDL-C) is associated with reduced risk of cardiovascular disease but inversely associated with bone mineral density.

Methods

We assessed the relationship between HDL-C and incident fractures using a prospective population-based cohort. In total 18,240 subjects had available data on HDL-C levels (mean age 69 years, 37% women, mean follow-up 13 years). Fracture endpoints were identified through

SUBMITTER: Sutton R 

PROVIDER: S-EPMC12847209 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature